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GE Healthcare China: Biacore's application in major disease research
The secrets hidden in DNA have been unveiled step by step, and scientists are faced with a new and huge challenge – interpreting the complex network of interactions between proteins encoded by DNA. It is becoming increasingly clear that a highly ordered interaction between proteins and peptides determines the fate of cells, such as proliferation, differentiation or death. The interaction between proteins strictly controls DNA replication, RNA transcription, protein translation, aggregation and degradation of macromolecules.as well as signal transduction processes. Essentially, all cellular functions involve protein interactions, and protein interactions can be said to be the basis for all organisms to maintain normal physiological functions. The occurrence of many diseases is closely related to changes in protein-protein interactions, such as neurodegenerative diseases, cancer, and infectious diseases. Therefore, study the conditions, occurrence processes and regulatory mechanisms of protein interactions, that is,
Understanding the fundamentals of various biological processes helps to clarify the molecular mechanisms of disease development and to find targets for therapeutic intervention.
Since the first BIACORETM system was introduced in 1990, the Bio-molecular Interaction Analysis System based on the Surface Plasmon Resonance Principle (SPR) has revealed the interaction between proteins, nucleic acids and other biomolecules with its unique perspective. The Biacore2 system helps scientists understand the interactions between biomolecules and the effects of these interactions through real-time, comprehensive, and label-free analysis.
Biological function.
The Biacore system provides researchers with a wealth of valuable information, including kinetics, affinity, specificity, thermodynamics, and nucleic acid activity concentrations, which are important in many areas. Whether it is a low molecular weight organic compound or a bio-macromolecule such as a protein, Biacore plays an irreplaceable role in characterizing its binding properties. At the same time, Biacore has developed a series of corresponding host and consumable products, including a variety of chips and kits, according to the needs of scholars in different fields. Biacore adheres to the mission of visual data quality and fully meets the high requirements of data quality, product performance and regulatory compliance in many applications such as basic research, drug development, process development, production and quality control
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